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Glucagon receptor activation is thought to increase energy expenditure and promote hepatic fat oxidation, potentially contributing to the substantial weight loss observed in early trials

Weight loss and blood sugar control may be enhanced by combining this with a GLP-1 receptor agonist

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Beyond tirzepatide, other incretin-based therapies have shown promise, such as retatrutide, a novel triple-hormone receptor agonist that simultaneously activates GLP-1, GIP, and glucagon receptors, with early-phase trials demonstrating profound effects on weight reduction [36]

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